Polyphenols Inhibit Band 3 Protein of the Erythrocyte Membrane
نویسندگان
چکیده
The effect of selected potential inhibitors of anion transport mediated by the Band 3 protein of the erythrocyte membrane was studied by the electron spin resonance (ESR) technique using Tempo-phosphate spin probe. No inhibition of Band 3-mediated transport by 1-cyano-4-hydroxycinnamic acid, inhibitor of monocarboxylate transporters (MCT) was found but inhibition by some polyphenols (curcumin > naringin > quercetin > luteolin > kaempferol) was observed. This effect does not seem important physiologically but may become relevant e. g. in cases of extensive consumption of curcuma of other dietary supplements. Key-Words Band 3 protein; erythrocyte; anion transport; polyphenols; flavonoids; curcumin; naringin; quercetin
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